ChemInform Abstract: Enantioselective and Convergent Synthesis of the 20-Membered Lactam Aglycon of Vicenistatin Antitumor Antibiotic.

✍ Scribed by Y. MATSUSHIMA; H. ITOH; T. EGUCHI; K. KAKINUMA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 36 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199850278

✦ Synopsis

Enantioselective and Convergent Synthesis of the 20-Membered Lactam Aglycon of Vicenistatin Antitumor Antibiotic.

-The synthesis of the macrolactam skeleton (IX) of vicenistatin is described. This procedure contains the creation of two novel stereogenic centers by coupling of the previously prepared compounds (I) and (II). Further studies on preparation of the aminosugar moiety of vicenistatin are in progress. -(MATSUSHIMA,