ChemInform Abstract: Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by Readily Available Chiral Amino Alcohol Based Ligands.

✍ Scribed by Zhen Li; Veena Upadhyay; Ann E. DeCamp; Lisa DiMichele; Paul J. Reider

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 30 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199949033

✦ Synopsis

1999 stereochemistry stereochemistry (general, optical resolution) O 0030

49 -033

Enantioselective Alkynylation of Aromatic Aldehydes Catalyzed by Readily Available Chiral Amino Alcohol Based Ligands.

-In the presence of 0.1 equivalents of chiral ligands PYR or IND a variety of aromatic aldehydes are converted to the corresponding chiral propargylic alcohols with very good enantioselectivities and yields. The mild method does not require strong base or transmetalation. NMR studies illustrate for the first time the role of ligands in the formation of chiral zinc-acetylide species. - (LI, ZHEN;