✦ LIBER ✦
ChemInform Abstract: Enantiomerically Pure Highly Functionalized α-Amino Ketones from the Reaction of Chiral Cyclic N-(9-Phenylfluoren-9-yl) α-Amido Esters with Organolithium Reagents.
✍ Scribed by E. FERNANDEZ-MEGIA; J. M. IGLESIAS-PINTOS; F. J. SARDINA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 38 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Enantiomerically Pure Highly Functionalized α-Amino Ketones from the Reaction of Chiral Cyclic N-(9-Phenylfluoren-9-yl) α-Amido Esters with Organolithium Reagents.
-Treatment of the cyclic αand β-amino esters (II), (V), and (VIII) with organolithium compounds is found to give the corresponding ketones in high yields with complete retention of enantiomeric purity. However, starting from the analogue (XI) considerable amounts of the undesired tertiary alcohol (XIII) are also formed.