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ChemInform Abstract: Enantiomerically Pure Cyclopropylamines via C—B to C—N Conversion.

✍ Scribed by Joerg Pietruszka; Gemma Solduga

Publisher
John Wiley and Sons
Year
2008
Weight
34 KB
Volume
39
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

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Lithiation of the L-proline derived 2-trichloromethyloxazolidin-5-one (I) and following reaction with alkyl halides yields the 4-substituted derivatives (III) with excellent diastereoselectivity. They can be easily cleaved to the proline esters (V). Hydrolysis or methanolysis of the N,O-acetal funct