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ChemInform Abstract: Enantio- and Diastereoselective Construction of 4,9-Dimethylspiro[4.4]nonane-2,7-dione Using Rh-Catalyzed Asymmetric Cyclization.

✍ Scribed by Masakazu Tanaka; Miyuki Takahashi; Eishi Sakamoto; Masanori Imai; Akiko Matsui; Masakazu Fujio; Kazuhisa Funakoshi; Kiyoshi Sakai; Hiroshi Suemune


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
32
Category
Article
ISSN
0931-7597

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Enantio- and Diastereoselective Synthesi
✍ Alexander Deiters; Birgit Wibbeling; Dieter Hoppe πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 76 KB πŸ‘ 1 views

Scheme 1. Synthesis of the cyclization precursor 1. (a) 4-Bromobut-2-enoic acid methyl ester (2.2 equiv., E/Z = 80 : 20), K 2 CO 3 (1.5 equiv.), 80 Β°C; (b) DIBAH (1.5 equiv.), hexane/THF, Β±78 Β°C; (c) NaH (0.25 equiv.), 6 (0.25 equiv.), THF, 60 Β°C; (d) LiCl (4.0 equiv.), n-BuLi (1.3 equiv.), CH 3 SO