ChemInform Abstract: Electrophilic Addition to 4-Thio Furanoid Glycal: A Highly Stereoselective Entry to 2′-Deoxy-4′-thio Pyrimidine Nucleosides.

✍ Scribed by K. HARAGUCHI; A. NISHIKAWA; E. SASAKURA; H. TANAKA; K. T. NAKAMURA; T. MIYASAKA

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 38 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199835269

✦ Synopsis

Three 4-thio furanoid glycals (III) and (V) are synthesized and converted stereoselectively to pyrimidine nucleosides, e.g. (VIII)-(X). In addition, (Xb) is reduced to give the corresponding 2'-deoxy derivative (XI) which shows activity against herpes virus.