ChemInform Abstract: Electroorganic Chemistry. Part 155. Electroreductive Coupling of Aliphatic Amides. A Useful Method for the Synthesis of α-Amino Ketones.

✍ Scribed by S. KASHIMURA; M. ISHIFUNE; Y. MURAI; H. MURASE; M. SHIMOMURA; T. SHONO

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 29
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199844079

✦ Synopsis

Electroorganic Chemistry. Part 155. Electroreductive Coupling of Aliphatic Amides. A Useful Method for the Synthesis of α-Amino Ketones.

-Cathodic reduction of aliphatic amides (I) in the presence of trimethylsilyl chloride (II) using magnesium electrodes is described. The enol ether coupling products (III) are isolated and hydrolyzed to the corresponding α-amino ketones (IV).