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ChemInform Abstract: Efficient Tautomerization Hydrazone—Azomethine Imine under Microwave Irradiation. Synthesis of [4,3′] and [5,3′]Bipyrazoles.

✍ Scribed by A. ARRIETA; J. R. CARRILLO; F. P. COSSIO; A. DIAZ-ORTIZ; M. J. GOMEZ-ESCALONILLA; A. DE LA HOZ; F. LANGA; A. MORENO

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
30
Category
Article
ISSN
0931-7597

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✦ Synopsis

Efficient Tautomerization Hydrazone-Azomethine Imine under Microwave Irradiation. Synthesis of [4,3'] and [5,3']Bipyrazoles.

-Microwave irradiation induces a thermal isomerization of pyrazolyl hydrazones to the corresponding azomethine imines, which undergo in situ 1,3-dipolar cycloaddition with electron-poor dipolarophiles to furnish bipyrazolyl adducts [cf. (III), (V)/(VI), (IX)/(X), (XI), (XIII)] in moderate to good yields. Microwave irradiation not only accelerates the reaction but also induces cycloaddition of dipolarophiles that do not react under classical heating conditions.

-(ARRIETA, A.; CARRILLO,

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