ChemInform Abstract: Efficient Synthesis of 1-Amino-2-naphthalenecarboxylic Acid Derivatives via a Sequential Michael Addition/Enolate-Nitrile Coupling Route and Its Application to Facile Preparation of 9-Amino Analogues of Arylnaphthofuranone Lignans.

✍ Scribed by K. KOBAYASHI; T. UNEDA; K. TAKADA; H. TANAKA; T. KITAMURA; O. MORIKAWA; H. KONISHI

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 39 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199725090

✦ Synopsis

1997 carboxylic acid derivatives carboxylic acid derivatives (naphthalene compounds) Q 0950

25 -090

Efficient Synthesis of 1-Amino-2-naphthalenecarboxylic Acid Derivatives via a Sequential Michael Addition/Enolate-Nitrile Coupling Route and Its Application to Facile Preparation of 9-Amino Analogues of Arylnaphthofuranone Lignans.

-The title new efficient route to acid derivatives such as (IV) uses for the first time in organic synthesis intermediate 2-(α-lithioalkyl)benzonitriles. The method is applied to the first construction of lignan derivatives of type (XIII). -(KOBAYASHI, K.;