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ChemInform Abstract: Efficient Preparation of 3-Substituted Quinazolinediones Directly from Anthranilic Acids and Isocyanates.

โœ Scribed by Natalie Koay; Louis-Charles Campeau

Publisher
John Wiley and Sons
Year
2011
Weight
23 KB
Volume
42
Category
Article
ISSN
0931-7597

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Efficient preparation of 3-substituted q
Efficient preparation of 3-substituted quinazolinediones directly from anthranilic acids and isocyanates
โœ Natalie Koay; Louis-Charles Campeau ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 149 KB

An efficient and practical synthesis of 3-substituted quinazolinediones is described. The protocol uses readily available isocyanates and anthranilic acids as precursors in a one-pot operation and has been demonstrated on >50 g scale. Isolation of the products via filtration directly from the reacti