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ChemInform Abstract: Efficient Biomimetic-Type Synthesis of the Benzo[a]naphthacenequinone Antibiotics G-2A (Ia) and G-2N (Ib).

โœ Scribed by Karsten Krohn; Sven Bernhard


Publisher
John Wiley and Sons
Year
2010
Weight
25 KB
Volume
31
Category
Article
ISSN
0931-7597

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Efficient Biomimetic-Type Synthesis of t
โœ Karsten Krohn; Sven Bernhard ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 279 KB ๐Ÿ‘ 1 views

Trioxo ester 15 was prepared by attachment of two vicinal C-16 regioselectively in one operation. Deprotection of 16 afforded the antibiotic G-2A (1) and decarboxylation of 1 4 and C-6 ketide side chains on the anthraquinone core (6b). Mild base treatment of 15 initiated successive aldol lead to G-2