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ChemInform Abstract: Efficient and Selective Demethylation of Heteroaryl Methyl Ethers in the Presence of Aryl Methyl Ethers.

✍ Scribed by Ajay Soni; Akhilesh Dutt; Viswajanani Sattigeri; Ian A. Cliffe

Publisher
John Wiley and Sons
Year
2011
Weight
30 KB
Volume
42
Category
Article
ISSN
0931-7597

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✍ Simonβ€…W. Breeden; Andrew Coop; Stephenβ€…M. Husbands; Johnβ€…W. Lewis πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 German βš– 59 KB πŸ‘ 2 views

In the pursuit of ring-constrained analogues of buprenorphine, we wished to prepare 6-O-demethylated analogues of the thevinols and orvinols. Previously it had been disclosed that lithium aluminum hydride (LAH) in THF containing a chlorinated solvent could achieve this transformation. Here we report