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ChemInform Abstract: Efficient and Convenient Route to (Z)-α,β-Unsaturated Difluoromethyl Ketones Based on the Reaction of 2,3,3-Trifluoro-1- tosyloxy-1-propenyllithium with Carbonyl Compounds.

✍ Scribed by K. FUNABIKI; T. OHTSUKI; T. ISHIHARA; H. YAMANAKA


Book ID
112033579
Publisher
John Wiley and Sons
Year
2010
Weight
33 KB
Volume
27
Category
Article
ISSN
0931-7597

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Highly efficient and stereoselective acc
✍ Kazumasa Funabiki; Yoshitaka Fukushima; Tomomi Inagaki; Eiji Murata; Masaki Mats 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 254 KB

2,3,3-Trifluoro-l-pmpenyl p-chlorobenzenesulfonate (1), readily available from 2,2,3,3tetrafluoropmpanol, reacted smoothly with various Grignard reagents at 50 °(3 to afford the corresponding (Z)-a, fl-difluoroallyl alcohols 2 in moderate to excellent yields. These alcohols were smoothly hydrolyzed