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ChemInform Abstract: Effective Synthesis of 1,5-Disubstituted 2,1-Benzisothiazol-3(1H)-ones.

✍ Scribed by Rajendra K. Kharul; Pinkal N. Prajapati; Amol A. Thorave; Hardik A. Shah; Arghya Dhar; Darshan A. Joshi; Mukul R. Jain; Pankaj R. Patel; S. S. Pancholi

Book ID: 112043718
Publisher: John Wiley and Sons
Year: 2012
Weight: 31 KB
Volume: 43
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201218141

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Stereoselective Synthesis of 1,3-Disubstituted Hexahydro-1,4diazepin-2-ones. -A fast and facile asymmetric synthesis of the title compounds (VI), a kind of constrained peptides, involving the diastereoselective alkylation of optically pure hydroxylactam (IV) as the key step is described.