ChemInform Abstract: Double Diastereoselective, Nucleophile-Catalyzed Aldol Lactonizations (NCAL) Leading to β-Lactone Fused Carbocycles and Extensions to β-Lactone Fused Tetrahydrofurans.

✍ Scribed by Kay A. Morris; Kevin M. Arendt; Seong Ho Oh; Daniel Romo

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 63 KB
• Volume: 41
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201051092

✦ Synopsis

Abstract

It is demonstrated, that aldol lactonization of ω‐carbonyl substituted carboxylic acids with Mukaiyama′s reagent can proceed with double diastereodifferentiation.