ChemInform Abstract: Domino Hydroformylation—Wittig Reactions.

✍ Scribed by Bernhard Breit; Stephan K. Zahn

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 31 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199931031

✦ Synopsis

Domino Hydroformylation-Wittig Reactions.

-The first domino hydroformylation-Wittig process as well as the first domino hydroformylation-Wittig-hydrogenation process with both methallyl or homomethallyl alcohols as alkenic substrates is presented. For disubstituted Wittig ylides (II), the stereoselective formation of a trisubstituted double bond and a C-C single bond takes place in a single operational step, combined with the generation of a new stereogenic center with high levels of stereochemistry. Mono-substituted Wittig ylides (V) give saturated products as result of hydrogenation of the intermediately formed double bond.

-(BREIT, BERNHARD; ZAHN,