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ChemInform Abstract: Discovery of R-142086 as a Factor Xa (FXa) Inhibitor: Syntheses and Structure—Activity Relationships of Cinnamyl Derivatives.

✍ Scribed by Naoki Tanaka; et al. et al.


Publisher
John Wiley and Sons
Year
2009
Weight
18 KB
Volume
40
Category
Article
ISSN
0931-7597

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✍ H. TERAUCHI; A. TANITAME; K. TADA; K. NAKAMURA; Y. SETO; Y. NISHIKAWA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 35 KB 👁 2 views

Nicotinamide Derivatives as a New Class of Gastric H+/K+-ATPase Inhibitors. Part 1. Synthesis and Structure-Activity Relationships of N-Substituted 2-(Benzhydryl-and benzylsulfinyl)nicotinamides. -A series of title compounds, e.g. (IV), (VIII), (IX), and (X), is synthesized. Acid activation convert