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ChemInform Abstract: Discovery of Molecules for the Treatment of Neuropathic Pain: Synthesis, Antiallodynic and Antihyperalgesic Activity of 5-(4-Nitrophenyl)furoic-2-acid Hydrazones.

✍ Scribed by Perumal Yogeeswari; Niloufer Menon; Arvind Semwal; Muralidharan Arjun; Dharmarajan Sriram

Publisher: John Wiley and Sons
Year: 2011
Weight: 36 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201141088

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✦ Synopsis

Abstract

Aldehydes and ketones (III) react with hydrazide (II) under microwave irradiation to furoic acid hydrazones (IV), which cause antinociceptive actions in the peripheral nerve injury model of neuropathic pain.

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