ChemInform Abstract: Discovery of an Imidazopyridine-Containing 1,4-Benzodiazepine Nonpeptide Vitronectin Receptor (αvβ3) Antagonist with Efficacy in a Restenosis Model.

✍ Scribed by Richard M. Keenan; M. Amparo Lago; William H. Miller; ET AL. ET AL.

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199911294

✦ Synopsis

Discovery of an Imidazopyridine-Containing 1,4-Benzodiazepine Nonpeptide Vitronectin Receptor (αvβ3) Antagonist with Efficacy in a Restenosis Model. -Among a variety of title compounds of type (I) and (II) the derivative (II) has sufficient potency and in vivo pharmacokinetics for demonstration of efficacy in a rat restenosis model. -(KEENAN, RICHARD