ChemInform Abstract: Direct Asymmetric α-Hydroxymethylation of Ketones in Homogeneous Aqueous Solvents.

✍ Scribed by Monika Paternak; Joanna Paradowska; Maria Rogozinska; Jacek Mlynarski

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 29 KB
• Volume: 41
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201046054

✦ Synopsis

Abstract

Aldol reactions of cyclic ketones with aqueous formaldehyde are catalyzed by a chiral prolinamide based zinc complex to afford the corresponding adducts with high enantioselectivity.