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ChemInform Abstract: Direct Asymmetric Bromination of Aldehydes Catalyzed by a Binaphthyl-Based Secondary Amine: Highly Enantio- and Diastereoselective One-Pot Synthesis of Bromohydrins.

✍ Scribed by Taichi Kano; Fumitaka Shirozu; Keiji Maruoka

Publisher: John Wiley and Sons
Year: 2011
Weight: 48 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201108022

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✦ Synopsis

Abstract

The bromination of aldehydes (I) in the presence of a chiral binaphthyl catalyst (BNS) followed by reduction of the intermediate α‐bromoaldehyde gives rise to bromohydrins (II) with high enantioselectivity.

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