ChemInform Abstract: Direct Aldol Condensation Reaction of Ethyl Diazoacetate with Trifluoromethyl Ketones.
โ Scribed by Han-Feng Cui; Lian Wang; Li-Jun Yang; Jing Nie; Yan Zheng; Jun-An Ma
- Publisher
- John Wiley and Sons
- Year
- 2012
- Weight
- 15 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0931-7597
No coin nor oath required. For personal study only.
โฆ Synopsis
Abstract
In the presence of ZnMe~2~, the title reaction affords a series of fluorinated aldol adducts in good to excellent yields.
๐ SIMILAR VOLUMES
## Abstract ZnEt~2~ in combination with DMEDA is optimal for the title process to yield cross aldol products under mild conditions.
Reactions of Ethyl Diazoacetate with Thioketones. -The 1,3-dipolar cycloaddition of ethyl diazoacetate (II) with thioketones is investigated. The most reactive dipolarophiles (I) give 1,3-dithiolanes, e.g. (III), (V), (VI) and (VIII). Sterically crowded thioketones (IX) and (XII) as well as the less
## Abstract The derivatives (VI), (VII) and (IX) also undergo highly enantioselective aldol reaction.