ChemInform Abstract: Dimerization of Knoevenagel Condensation Products Obtained from Simple Unconjugated and α,β-Unsaturated Ketones.

✍ Scribed by Conor N. O'Callaghan; T. Brian H. McMurry

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 37 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199951040

✦ Synopsis

Dimerization of Knoevenagel Condensation Products Obtained from Simple Unconjugated and α,β-Unsaturated Ketones.

-The reactions of β-enones and unconjugated ketones with malononitrile (V) are examined to obtain dicyanomethylene derivatives as potential tyrosine kinase inhibitors. When the methylene component of the Knoevenagel condensation is less reactive than (V), dimerization occurs in a different manner, cf. (III). The reaction of (II) with "malononitrile dimer" (VII) yields the simple 1:1 product (VIII) along with traces of the 1:2 product (IX). In the case of β-enones further variations of the products obtained are observed. In addition, some corrections of literature protocols are given. -(O'CALLAGHAN, CONOR