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ChemInform Abstract: Digitalis-Like Compounds: Synthesis and Biological Evaluation of 3. beta.-(Aminoalkylthio) Derivatives.

โœ Scribed by M. GOBBINI; A. BENICCHIO; G. PADOANI; M. TORRI; P. MELLONI

Book ID
101844686
Publisher
John Wiley and Sons
Year
2010
Weight
38 KB
Volume
28
Category
Article
ISSN
0931-7597

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Digitalis-like compounds: Synthesis and
Digitalis-like compounds: Synthesis and biological evaluation of 3ฮฒ-(aminoalkylthio) derivatives
โœ Mauro Gobbini; Alessandra Benicchio; Gloria Padoani; Marco Torri; Piero Melloni ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 209 KB

The synthesis and the binding affinities to the digitalis receptor on the Na+,K+-ATPase of a series of 3~-(aminoalkylthio) digitalis derivatives are described. In most cases these derivatives showed a higher binding affinity than that of the corresponding 3~-hydroxy and 313-mercapto parent compounds