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ChemInform Abstract: Different Mechanisms of Oxidative Stress and Neurotoxicity for Alzheimer′s Aβ(1—42) and Aβ(25—35).

✍ Scribed by Sridhar Varadarajan; Jaroslaw Kanski; Marina Aksenova; Christopher Lauderback; D. Allan Butterfield

Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
32
Category
Article
ISSN
0931-7597

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## Abstract Glutathione (GSH) is an important endogenous antioxidant found in millimolar concentrations in the brain. GSH levels have been shown to decrease with aging. Alzheimer's disease (AD) is a neurodegenerative disorder associated with aging and oxidative stress. Aβ(1–42) has been shown to in