ChemInform Abstract: High 1,6-Diastereos
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H.-C. ZHANG; B. D. HARRIS; C. A. MARYANOFF; B. E. MARYANOFF
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Article
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2010
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John Wiley and Sons
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High 1,6-Diastereoselectivity in the Hydride Reduction of an Acyclic Ketone Substrate via Bicyclic Chelation Control. -Reduction of the .epsilon.-hydroxyketone (I) with (R)-Alpine hydride provides the corresponding diol (II) with strong preponderance of the anti-diastereomer. The high degree of ste