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ChemInform Abstract: Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones Through a Double Reformatsky Reaction.

✍ Scribed by Stephen N. Greszler; Jeffrey S. Johnson

Publisher
John Wiley and Sons
Year
2009
Weight
45 KB
Volume
40
Category
Article
ISSN
0931-7597

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✦ Synopsis

Abstract

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Diastereoselective Synthesis of Pentasub
Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction
✍ Stephen N. Greszler; Jeffrey S. Johnson 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 1 views

## Abstract **Three contiguous stereocenters** can be established with remarkable diastereoselectivity in a double Reformatsky sequence. Densely functionalized γ‐butyrolactones were assembled rapidly by this approach, in which a ketone is used as the terminal electrophile (see scheme). Secondary tr

Diastereoselective Synthesis of Pentasub
Diastereoselective Synthesis of Pentasubstituted γ-Butyrolactones from Silyl Glyoxylates and Ketones through a Double Reformatsky Reaction
✍ Stephen N. Greszler; Jeffrey S. Johnson 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 1 views

## Abstract **Drei benachbarte Stereozentren** werden in einer bemerkenswert diastereoselektiven doppelten Reformatsky‐Sequenz erzeugt. Dieser Ansatz, bei dem ein Keton als abschließendes Elektrophil dient, lieferte sehr rasch hoch funktionalisierte γ‐Butyrolactone (siehe Schema), die für zahlreich