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ChemInform Abstract: Diastereoselective Nucleophilic Addition of Acetylide to N-Benzyl-2, 3-O-isopropylidene-D-glyceraldehyde Nitrone (BIGN). Stereodivergent Synthesis of β-Hydroxy-α-(hydroxyamino)- and β-Hydroxy-α-amino Acids.

✍ Scribed by P. MERINO; S. FRANCO; F. L. MERCHAN; T. TEJERO


Publisher
John Wiley and Sons
Year
2010
Weight
39 KB
Volume
29
Category
Article
ISSN
0931-7597

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ChemInform Abstract: Nucleophilic Additi
✍ P. MERINO; E. CASTILLO; S. FRANCO; F. L. MERCHAN; T. TEJERO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB

Nucleophilic Additions of Grignard Reagents to N-Benzyl-2,3-O-isopropylidene-D-glyceraldehyde Nitrone (BIGN). Synthesis of (2S,3R) and (2S,3S)-3-Phenylisoserine. -The addition of Grignard reagents to the nitrone (I) proceeds with high anti or syn selectivity depending on the Lewis acid used. The re