ChemInform Abstract: Diastereoselective Aldol Condensation with 2-(β-Ethoxycarbonyl)oxazolidine Derived from Norephedrine. A Chiral Masked Synthon of Ethyl Formylacetate.

✍ Scribed by Maria Garcia-Valverde; Javier Nieto; Rafael Pedrosa; Martina Vicente

• Book ID: 101885654
• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 33 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199933147

✦ Synopsis

Diastereoselective Aldol Condensation with 2-(β-Ethoxycarbonyl)oxazolidine Derived from Norephedrine. A Chiral Masked Synthon of Ethyl Formylacetate. -The aldol condensation of the title synthon (I) with aromatic aldehydes allows the synthesis of β-hydroxy esters with moderate to high diastereoselectivity. The latter can smoothly be converted into 2-aminomethyl-1,3-diols. -(GARCIA-VALVERDE, MARIA;