Diaryl indenes and benzofurans: Novel cl
โ
Horng-Chih Huang; Timothy S. Chamberlain; Karen Selbert; Carol M. Koboldt; Peter
๐
Article
๐
1995
๐
Elsevier Science
๐
English
โ 219 KB
Novel series of diaryl indenes and benzofurans have been shown to be potent and selective COX-2 inhibitors. A structuro-actlvity relationship study suggests that the conversion of sulfones to sulfonamides affords potent, but slightly less selective COX-2 lnhibitors, and that for benzofurans the 3-ha