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ChemInform Abstract: Diaryl Indenes and Benzofurans: Novel Classes of Potent and Selective Cyclooxygenase-2 Inhibitors.

โœ Scribed by H.-C. HUANG; T. S. CHAMBERLAIN; K. SEIBERT; C. M. KOBOLDT; P. C. ISAKSON; D. B. REITZ


Book ID
112027910
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
27
Category
Article
ISSN
0931-7597

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Diaryl indenes and benzofurans: Novel cl
โœ Horng-Chih Huang; Timothy S. Chamberlain; Karen Selbert; Carol M. Koboldt; Peter ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 219 KB

Novel series of diaryl indenes and benzofurans have been shown to be potent and selective COX-2 inhibitors. A structuro-actlvity relationship study suggests that the conversion of sulfones to sulfonamides affords potent, but slightly less selective COX-2 lnhibitors, and that for benzofurans the 3-ha