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ChemInform Abstract: Development of Non-Peptidic Farnesyltransferase Inhibitors Based on the Ca1a2 of Ras-CaaX.

✍ Scribed by Hee-Yoon Lee; Tae-Gyu Chun; Hyun-Moo Choi; Jeong-Hun Sohn; Byoung-Mog Kwon


Publisher
John Wiley and Sons
Year
2009
Weight
19 KB
Volume
40
Category
Article
ISSN
0931-7597

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## Abstract Plasmepsin II (PMII), a malarial aspartic protease involved in the catabolism of hemoglobin in parasites of the genus __Plasmodium__, and renin, a human aspartic protease, share 35% sequence identity in their mature chains. Structures of 4‐arylpiperidine inhibitors complexed to human re