ChemInform Abstract: Development of Bioactive Functions in Hydrangeae Dulcis Folium. Part 6. Syntheses of Thunberginols A and F and Their 3′-Deoxy-Derivatives Using Regiospecific Lactonization of Stilbene Carboxylic Acid: Structures and Inhibitory Activity on Histamine Release of Hydramacrophyllols A and B.
✍ Scribed by M. YOSHIKAWA; H. SHIMADA; N. YAGI; N. MURAKAMI; H. SHIMODA; J. YAMAHARA; H. MATSUDA
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Development of Bioactive Functions in Hydrangeae Dulcis Folium. Part 6. Syntheses of Thunberginols A and F and Their 3'-Deoxy-Derivatives Using Regiospecific Lactonization of Stilbene Carboxylic Acid: Structures and Inhibitory Activity on Histamine Release of Hydramacrophyllols A and B.
-Thunberginol A (IV) and F (X) (constituents of Hydrangeae Dulcis Folium) and the corresponding 3'-deoxyderivatives (V) and (XI) are synthesized in order to study their antiallergic activity. Hydramacrophyllos A and B (cf. (XII)), isolated together with (IV) and (X), are found to inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction. -(YOSHIKAWA, M.;