ChemInform Abstract: Design, Synthesis and Pharmacological Test of a Quinoline Based, Nonpeptidic Analogue of Neurotensin(8-13).

✍ Scribed by F. HONG; Y.-P. PANG; B. CUSACK; E. RICHELSON

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 28
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199751158

✦ Synopsis

Design, Synthesis and Pharmacological Test of a Quinoline Based, Nonpeptidic Analogue of Neurotensin(8-13).

-The analogue (VI) of neurotensin(8-13) is synthesized using a multiple template approach to non-peptidic mimetics of neuropeptides. Analogue ( VI) is found to be less active in binding to the neurotensin receptors than previously reported mimetics which are partial analogues of neurotensin (8-13). The present study reveals a mistake in the synthesis of these mimetics. -(HONG, F.;