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ChemInform Abstract: Design, Synthesis, and Molecular-Modeling Study of Aminothienopyridine Analogues of Tacrine for Alzheimer′s Disease.

✍ Scribed by Mohga M. Badran; Maha Abdel Hakeem; Suzan M. Abuel-Maaty; Afaf El-Malah; Rania M. Abdel Salam


Publisher
John Wiley and Sons
Year
2011
Weight
29 KB
Volume
42
Category
Article
ISSN
0931-7597

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Design, Synthesis, and Molecular-modelin
✍ Mohga M. Badran; Maha Abdel Hakeem; Suzan M. Abuel-Maaty; Afaf El-Malah; Rania M 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

## Abstract 2‐Amino‐3‐cyanothiophenes were successfully condensed with a number of cycloalkanones to afford tacrine analogues in a one‐step reaction mediated with Lewis acid. The newly synthesized compounds have been tested for their ability to inhibit acetylcholine esterase (AChE) activity using t