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ChemInform Abstract: Design, Synthesis, and Characterization of a Novel Hexaazacyclophane and Interactions with d(CGCA3T3GCG)2, ctDNA and T4DNA.

✍ Scribed by T. C. BRUICE; Y. C. YIP; A. BLASKO; F. C. LIGHTSTONE; K. A. BROWNE; M. E. PETYAK; J. LUO

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199741208

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✦ Synopsis

Design, Synthesis, and Characterization of a Novel Hexaazacyclophane and Interactions with d(CGCA3T3GCG)2, ctDNA and T4DNA. -The title compound (I), which is prepared from 2,6-naphthalene dicarboxylic acid and (3-bromopropyl)phthalimide, is characterized by X-ray analysis, 1H NMR and fluorescence spectroscopy. Its structural shape is complementary to the major groove of B-DNA. At pH 7.0 the equilibrium constants for the binding of (I) to ctDNA and T4DNA are 1. 2•105 and 1.8•106, respectively. Association of (I) to d( CGCA3T3GCG)2 leads to a polymer. -

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