ChemInform Abstract: Design, Reactivities, and Practical Application of Dialkylzinc Hydride Ate Complexes Generated in situ from Dialkylzinc and Metal Hydride. A New Methodology for Activation of NaH and LiH under Mild Conditions.
✍ Scribed by M. UCHIYAMA; S. FURUMOTO; M. SAITO; Y. KONDO; T. SAKAMOTO
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 40 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Design, Reactivities, and Practical Application of Dialkylzinc Hydride Ate Complexes Generated in situ from Dialkylzinc and Metal Hydride. A New Methodology for Activation of NaH and LiH under Mild Conditions. -The study on the reactivities of dialkylzinc hydride ate complexes toward carbonyl compounds reveals that dimethylzink hydrides are the most powerful and selective zincates for the reduction of the carbonyl group. To discuss and clarify the active species and the mechanism of this reduction some diastereoselective reductions of some carbonyl compounds with an adjacent chiral center are carried out. A catalytic version of this reducing system by using LiH-ZnMe 2 -ultrasound is developed. -(UCHIYAMA, M.; FURUMOTO, S.;