## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
ChemInform Abstract: Design and Synthesis of Unsymmetrical Peptidyl Urea Inhibitors of Aspartic Peptidases.
β Scribed by Natalie A. Dales; Regine S. Bohacek; Kenneth A. Satyshur; Daniel H. Rich
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 26 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0931-7597
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## Abstract __Unsaturated and fluorinated analogues of aspartylβΞ²βphosphate were synthesised as potential inhibitors of the bacterial enzyme aspartate semialdehyde dehydrogenase (ASAβDH). Acetylenic and__ Z__βolefinic analogues showed competitive inhibition, but an__ E__βolefinic analogue was inact
The bisbenzotriazole compound (I) is a safe, mild, and versatile reagent for the synthesis of unsymmetrical tetrasubstituted ureas of type (Va)-(Ve). It can also be used for the preparation of di-and trisubstituted ureas such as (Vf) and (Vg).