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ChemInform Abstract: Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase.

✍ Scribed by Nigel J. Liverton; et al. et al.

Publisher: John Wiley and Sons
Year: 2010
Weight: 32 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199939120

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## Abstract ## Objective FR167653 is a potent inhibitor of p38 mitogen‐activated protein kinase (MAPK) and inhibits tumor necrosis factor α (TNFα) and interleukin‐1β (IL‐1β) production in inflammatory cells. In this study we investigated the effect of FR167653 on collagen‐induced arthritis (CIA).