ChemInform Abstract: Demethylation—Sulfonation of 2′,3′,4′-Trimethoxyflavones.

✍ Scribed by Amar Habsaoui; Jose Luis Franquet Cami; Emile M. Gaydou; Jean-Claude Wallet

• Publisher: John Wiley and Sons
• Year: 2010
• Weight: 32 KB
• Volume: 30
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.199945158

✦ Synopsis

Demethylation-Sulfonation of 2',3',4'-Trimethoxyflavones.

-Treatment of flavones (I) in conc. H 2 SO 4 results in total demethylation and sulfonation at the 5'-position of the phenyl ring, whereas the 5-hydroxy derivative (III) is demethylated and disulfonated at the 8-and 5'-position. Based on the results of NMR experiments a multi-step reaction mechanism is proposed.