ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis. Part 57. Convenient Syntheses and Biological Activity of Novel ω-trans-(Bicyclopropyl)- and ω-(Bicyclopropylidenyl)-Substituted Fatty Acids and Their Derivatives.

Convenient Syntheses and Biological Acti

Convenient Syntheses and Biological Activity of Novel ω-trans-(Bicyclopropyl)- and ω-(Bicyclopropylidenyl)-Substituted Fatty Acids and Their Derivatives

✍ Sandra Löhr; Carsten Jacobi; Andre Johann; Gerhard Gottschalk; Armin de Meijere 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 261 KB 👁 1 views

A series of ω-trans-(bicyclopropyl)-substituted fatty acids 9 has been synthesized from bicyclopropylidene (5) starting by deprotonation with n-butyllithium. Electrophilic substitution of lithiobicyclopropylidene with THP-protected ω-iodoalkanols 6 gave the THP-protected (bicyclopropylidenyl)alkanol