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ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis. Part 51. An Easy Access to 1-Azaspiropentane-2-carboxamides — The First Derivatives of a New Type of Amino Acids.

✍ Scribed by Markus Tamm; Michael Thutewohl; Carsten B. Ricker; M. Teresa Bes; Armin de Meijere


Publisher
John Wiley and Sons
Year
2010
Weight
37 KB
Volume
30
Category
Article
ISSN
0931-7597

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An Easy Access to 1-Azaspiropentane-2-ca
✍ Markus Tamm; Michael Thutewohl; Carsten B. Ricker; M. Teresa Bes; Armin de Meijer 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 212 KB 👁 1 views

Azaspiropentanecarboxamides 10 and 12 are formed with good (27-59%, 12-48%), while the corresponding esters 9 could only be obtained in poor yields (4-14%). The new αremarkable ease in two steps in a one-pot operation from methyl 2-chloro-2-cyclopropylideneacetate (4) by addition of amino acid amide