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ChemInform Abstract: Coumarin Inhibitors of Gyrase B with N-Propargyloxy-carbamate as an Effective Pyrrole Bioisostere.

โœ Scribed by Anne-Marie Periers; Patrick Laurin; Didier Ferroud; Jean-Luc Haesslein; Michel Klich; Claudine Dupuis-Hamelin; Pascale Mauvais; Patrice Lassaigne; Alain Bonnefoy; Branislav Musicki


Publisher
John Wiley and Sons
Year
2010
Weight
32 KB
Volume
31
Category
Article
ISSN
0931-7597

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Coumarin inhibitors of gyrase B with N-p
โœ Anne-Marie Periers; Patrick Laurin; Didier Ferroud; Jean-Luc Haesslein; Michel K ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 183 KB

AbstractรThe synthesis and biological proยฎle in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3 H of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxycarbamate bioisostere leads to analogues w