Coumarin inhibitors of gyrase B with N-p
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Anne-Marie Periers; Patrick Laurin; Didier Ferroud; Jean-Luc Haesslein; Michel K
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Article
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2000
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Elsevier Science
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English
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AbstractรThe synthesis and biological proยฎle in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3 H of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxycarbamate bioisostere leads to analogues w