ChemInform Abstract: Copper(I)-Catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes.

✍ Scribed by Yongeun Kim; Hiroyuki Nakamura

• Publisher: John Wiley and Sons
• Year: 2012
• Weight: 31 KB
• Volume: 43
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201213074

✦ Synopsis

Copper(I)-Catalyzed Deacetylenative Coupling of Propargylic Amines: An Efficient Synthesis of Symmetric 1,4-Diamino-2-butynes. -The deacetylenative coupling reaction of two terminal propargylic amines is accomplished in the presence of a copper(I) catalyst and the absence of a base to give the diaminobutynes (II). In the presence of a base, the homocoupling product (IV) is formed. -(KIM, Y.;