ChemInform Abstract: Cooperative Catalytic Reactions Using Lewis Acids and Organocatalysts: Enantioselective Propargylic Alkylation of Propargylic Alcohols Bearing an Internal Alkyne with Aldehydes.

✍ Scribed by Kazuki Motoyama; Masahiro Ikeda; Yoshihiro Miyake; Yoshiaki Nishibayashi

• Publisher: John Wiley and Sons
• Year: 2011
• Weight: 37 KB
• Volume: 42
• Category: Article
• ISSN: 0931-7597
• DOI: 10.1002/chin.201135098

✦ Synopsis

Abstract

An optically active secondary amine is used as co‐catalyst in the title reaction affording the corresponding propargylic alkylated products in high yields as a mixture of two diastereoisomers with high enantioselectivity.