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ChemInform Abstract: Controlling Peptide Structure

✍ Scribed by C. L. WYSONG; T. S. YOKUM; M. L. MCLAUGHLIN; R. P. HAMMER


Publisher
John Wiley and Sons
Year
2010
Weight
27 KB
Volume
28
Category
Article
ISSN
0931-7597

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✦ Synopsis


Controlling Peptide Structure -(synthesis of Ξ±,Ξ±-disubstituted amino acids, used in the synthesis of secondary peptide structures by replacement of proteinogenic amino acids, potential antimicrobial agents; 50 refs.).


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Selective bond formation of biomolecule substrates requires synthetic chemistry in an aqueous, functional-grouprich environment to alter and control the structure, function, and aggregation state of biomolecules. Ideally, new methods would be non-denaturing, would utilize chemistry that is orthogona