✦ LIBER ✦
ChemInform Abstract: Construction of the ABC Ring System of Taxanes via Stereoselective One-Pot Three-Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether.
✍ Scribed by Takayuki Serizawa; Shigeru Miyamoto; Shinichiro Fuse; Takayuki Doi; Takashi Takahashi
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 29 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
The 1,4‐addition of cyclohexenone (II) to the protected cyanohydrin ether (I) and subsequent addition of formaldehyde (III) to the resulting enolate proceed stereoselectively to afford the AC‐ring system (IV).