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ChemInform Abstract: Conjugate Intra- and Intermolecular Addition Mediated by Methoxide Anion on Polymeric Support.

โœ Scribed by Cristiana Fava; Roberta Galeazzi; Eugenia Maria Gonzalez-Rosende; Mario Orena


Book ID
101903820
Publisher
John Wiley and Sons
Year
2001
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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Conjugate intra- and intermolecular addi
โœ Cristiana Fava; Roberta Galeazzi; Eugenia Maria Gonzalez-Rosende; Mario Orena ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 80 KB

By treatment with methoxide anion on polymeric support (IRA 900), chiral b-oxo or b-sulphonylamides 2 bearing an a,b-unsaturated ester gave 3,4-disubstituted pyrrolidin-2-ones 3 as easily separable diastereomeric mixtures in good yield and moderate-to-good stereoselection. The polymeric reagent was