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ChemInform Abstract: Computational Oral Absorption Simulation for Low-Solubility Compounds.

✍ Scribed by Kiyohiko Sugano

Publisher: John Wiley and Sons
Year: 2010
Weight: 15 KB
Volume: 41
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201008277

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Computational Oral Absorption Simulation

Computational Oral Absorption Simulation for Low-Solubility Compounds

✍ Kiyohiko Sugano 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 509 KB

## Abstract Bile micelles play an important role in oral absorption of low‐solubility compounds. Bile micelles can affect solubility, dissolution rate, and permeability. For the pH–solubility profile in bile micelles, the __Henderson__–__Hasselbalch__ equation should be modified to take bile‐micell

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