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ChemInform Abstract: Compounds Containing 2-Substituted Imidazole Ring for Treatment Against Human African Trypanosomiasis.

✍ Scribed by Bhupesh S. Samant; Mugdha G. Sukhthankar

Book ID: 102069633
Publisher: John Wiley and Sons
Year: 2011
Weight: 35 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201130121

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✍ Bhupesh S. Samant; Mugdha G. Sukhthankar 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 294 KB

A series of compounds containing 2-substituted imidazoles has been synthesized from imidazole and tested for its biological activity against human African trypanosomiasis (HAT). The 2-substituted 5-nitroimidazoles such as fexinidazole (7a) and 1-[4-(1-methyl-5-nitro-1H-imidazol-2-ylmethoxy)-pyridin-

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ChemInform Abstract: 1-Aryl-4-nitro-1H-imidazoles, a New Promising Series for the Treatment of Human African Trypanosomiasis.

✍ Bernadette Bourdin Trunz; Rafal Jedrysiak; David Tweats; Reto Brun; Marcel Kaise 📂 Article 📅 2011 🏛 John Wiley and Sons ⚖ 24 KB 👁 1 views

## Abstract Following a so‐called ANRORC reaction, several novel 1‐aryl‐4‐nitro‐1H‐imidazoles (III) are prepared.