✦ LIBER ✦
ChemInform Abstract: Comparative Lipase-Catalyzed Hydrolysis of Ethylene Glycol Derived Esters. The 2-Methoxyethyl Ester as a Protective Group in Peptide and Glycopeptide Synthesis.
✍ Scribed by M. GEWEHR; H. KUNZ
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 40 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Comparative Lipase-Catalyzed Hydrolysis of Ethylene Glycol Derived Esters. The 2-Methoxyethyl Ester as a Protective Group in Peptide and Glycopeptide Synthesis.
-The 2-methoxyethyl ester group is found to be a potent protecting group in the synthesis of various peptides and glycopeptides. It can be removed under mild conditions preventing any undesired attack at other linkages of the molecules like peptide and glycosidic bonds or other protecting groups. The regioselective hydrolysis of the diester (V) opens up a short and efficient route to aspartic acid synthons.